| Project/Area Number |
25861746
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TABATA Atsushi 徳島大学, ソシオテクノサイエンス研究部, 助教 (10432767)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ストレプトリジンS / 口腔連鎖球菌 / アンギノーサス群連鎖球菌 / β溶血 / 病原因子 / Streptococcus |
|---|
| Outline of Final Research Achievements |
In this study, we revealed that a homolog of streptolysin S (SLS), a typical peptide-type hemolytic factor secreted from Pyogenic group streptococci, was the β-hemolytic factor of β-hemolytic Anginosus group streptococci (β-AGS). Moreover, the investigation of cytotoxicity of β-hemolytic S. anginosus subsp. anginosus (β-SAA) dependent on the SLS homolog showed that relatively milder than hemolysis but distinguishable cell damage was induced in human oral squamous cell carcinoma under the co-culture condition with β-SAA. These results suggest the participation of SLS homolog secreted from β-AGS not only in β-hemolysis but also in cytotoxicity of β-AGS.
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