The machanism of the regulation of FGF signaling by Runx2 in skeletal development
| Project/Area Number |
25861748
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
ROKUTANDA Satoshi 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (60549608)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 頭蓋縫合早期癒合 / 四肢形成異常 / Runx2 / FGFシグナル / 骨芽細胞 / FGF / FGFR / 頭蓋縫合早期癒合症 / 肢芽形成 |
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| Outline of Final Research Achievements |
Gain of function mutations of fibroblast growth factor receptor (FGFR)1, FGFR2, FGFR3 cause craniosynostosis such as Apert, Crouzon, Pfeiffer, Muenke syndromes and Thanatophoric dysplasia. Further, Apert syndrome and Crouzon syndrome show limb defects. The mice, in which Runx2 was overexpressed in carvaria and limbs, showed craniosynostosis and limb defects. In the mice, FGF expression in limbs was abnormal, indicating that Runx2 is involved in the regulation of FGF signaling.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Cbfb regulates bone development by stabilizing Runx family proteins.2015
Author(s)
Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T.
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Journal Title
Journal of bone and mineral research
Volume: 30
Issue: 4
Pages: 706-714
DOI
Related Report
Peer Reviewed
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