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The machanism of the regulation of FGF signaling by Runx2 in skeletal development

Research Project

Project/Area Number 25861748
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionNagasaki University

Principal Investigator

ROKUTANDA Satoshi  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (60549608)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords頭蓋縫合早期癒合 / 四肢形成異常 / Runx2 / FGFシグナル / 骨芽細胞 / FGF / FGFR / 頭蓋縫合早期癒合症 / 肢芽形成
Outline of Final Research Achievements

Gain of function mutations of fibroblast growth factor receptor (FGFR)1, FGFR2, FGFR3 cause craniosynostosis such as Apert, Crouzon, Pfeiffer, Muenke syndromes and Thanatophoric dysplasia. Further, Apert syndrome and Crouzon syndrome show limb defects. The mice, in which Runx2 was overexpressed in carvaria and limbs, showed craniosynostosis and limb defects. In the mice, FGF expression in limbs was abnormal, indicating that Runx2 is involved in the regulation of FGF signaling.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Cbfb regulates bone development by stabilizing Runx family proteins.2015

    • Author(s)
      Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T.
    • Journal Title

      Journal of bone and mineral research

      Volume: 30 Issue: 4 Pages: 706-714

    • DOI

      10.1002/jbmr.2379

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bcl2 deficiency activates FoxO through Akt inactivation and accelerates osteoblast differentiation2014

    • Author(s)
      Moriishi T, Kawai Y, Komori H, Rokutanda S, Eguchi Y, Tsujimoto Y, Asahina I, Komori T
    • Journal Title

      PLoS One

      Volume: 9(1) Issue: 1 Pages: 86629-86629

    • DOI

      10.1371/journal.pone.0086629

    • NAID

      120006987119

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Cbfb は軟骨細胞分化・増殖および骨芽細胞分化に必要である2014

    • Author(s)
      秦昕、松尾友紀、姜晴、森石武史、六反田賢、宮崎敏博、小守壽文
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡市 福岡国際会議場
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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