Evaluation of novel antibacterial agents derived from oral cavity against Staphylococcus aureus to inhibit oral colonization.
Project/Area Number |
25861749
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Morphological basic dentistry
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Research Institution | Kagoshima University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 黄色ブドウ球菌 / 口腔内定着 / バクテリオシン / 二成分制御系 / 抗菌性因子 / 口腔内定着阻害 |
Outline of Final Research Achievements |
We evaluated a novel antibacterial agents against Staphylococcus aureus to inhibit oral colonization. We isolated Streptococcus sanguinis and Streptococcus parasanguinis which have antibacterial actuvuty against S. aureus. These bacteria produce hydrogen peroxide as antibacterial agent. Furthermore, two-component systems of S.aureus are revealed that related to the resistant system against hydrogen peroxide of S. sanguinis and bacteriocins produced by L. lactis and S. warneri. We consider that TCSs can be applied as a fixing inhibitors preventing oral colonization of S. aureus.
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Report
(3 results)
Research Products
(7 results)