Overall understanding of biogenesis mechanism of fimbriae in periodontal pathogen
| Project/Area Number |
25861752
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Aichi Gakuin University (2014-2015)
Asahi University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 慢性歯周炎 / 歯周病関連細菌 / Porphyromonas gingivalis / 線毛 / Mfa1 / FimA / アクセサリー分子 / 歯周病関連菌 / TypeIX分泌装置 / 歯周病 / 付随成分 |
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| Outline of Final Research Achievements |
Mfa1 fimbriae of Porphyromonas gingivalis, a major periodontal pathogen, is composed of five proteins of Mfa1-5, but there is limited information about their biogenesis mechanism. The aim of this study was to elucidate how fimbrial proteins were translocated to cell surface and were assembled on the cell surface. The following findings were obtained. (1) Mfa3-5 were involved in expression of fimbriae on the cell surface. (2) Gingipains were required for post transcriptional modification of Mfa3 and Mfa4. (3) Type IX secretion system was involved in integration of Mfa5 into fimbriae. These findings suggested the presence of a novel biogenesis mechanism of the P. gingivalis fimbriae.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Acyl-CoA reductase PGN_0723 utilizes succinyl-CoA to generate succinate semialdehyde in a butyrate-producing pathway of Porphyromonas gingivalis2016
Author(s)
1. Yoshida, Y., Sato, M., Kezuka, Y., Hasegawa, Y., Nagano, K., Takebe, J. and Yoshimura, F.
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Journal Title
Arch. Biochem. Biophys.
Volume: 596
Pages: 138-148
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Mfa4, an accessory protein of Mfa1 fimbriae, modulates fimbrial biogenesis, cell auto-aggregation, and biofilm formation in Porphyromonas gingivalis.2015
Author(s)
R. Ikai, Y. Hasegawa, M. Izumigawa, K. Nagano, Y. Yoshida, N. Kitai, R. J. Lamont, F. Yoshimura and Y. Murakami
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Journal Title
PLoS ONE
Volume: 10
Issue: 10
Pages: e0139454-e0139454
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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