Mechanism of oral ulcer-induced pain in rats
| Project/Area Number |
25861760
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
HITOMI Suzuro 九州歯科大学, 歯学部, 助教 (70548924)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口内炎 / 疼痛 / TRPV1 / 三叉神経節 / 疼痛関連行動 / 口腔粘膜 |
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| Outline of Final Research Achievements |
Although oral ulcers are induced as a side effect of chemo-radiotherapy in cancer patients, there are relatively few effective treatments for relief the oral ulcer-induced pain. In the present study, we investigated the pain mechanism in oral ulcer and determined analgesic effect of lidocaine derivative QX-314 on the pain in rats. Oral ulcer model rats induced spontaneous and mechanical- and chemical-evoked pain which is similar to clinical pain induced by oral ulcer. The pain is likely due to accelerated cell membrane permeability of substance in the ulcer region where the epithelial barrier was destroyed. QX-314 was effective on the oral ulcer-induced both spontaneous and mechanical pain relief long-lastingly.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats.2015
Author(s)
Hitomi S, Ono K, Miyano K, Ota Y, Uezono Y, Matoba M, Kuramitsu S, Yamaguchi K, Matsuo K, Seta Y, Harano N, Inenaga K.
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Journal Title
J Neurosci Methods
Volume: 239
Pages: 162-169
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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