Molecular biological analysis of disease developing mechanism of progressive condylar resorption

• Project/Area Number: 25861774
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tohoku University
• Principal Investigator: NOGAMI Shinnosuke 東北大学, 歯学研究科(研究院), 助教 (70573575)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 進行性下顎頭吸収 / 仮骨延長 / サイトカイン / 顎関節 / 炎症性サイトカイン / 下顎骨延長 / メカニカルストレス / 骨格性下顎後退症

Outline of Final Research Achievements

We investigated the influence of mechanical stress on the temporomandibular joint (TMJ) in a rabbit model. We divided the rabbits into 2 groups, traction and compressive, and compared them at each period.Tractional mechanical stress led to changes in the form of the condyle, including significantly reduced bone volume and decreased bone mineral density. In addition, the number of TRAP-positive cells was increased in the traction group during each period. Furthermore, subchondral bone formation disorders were more prominent in the traction group as compared to the compressive group.Our findings demonstrated that the TMJ may be more affected by tractional than compressive mechanical stress.Moreover, we speculate that condylar resorption is related to subchondral cells, though findings following immunohistochemical staining are needed as part of a future examination.

Research Products

• [Journal Article] 口蓋に生じた膿原性肉芽腫の1例 (2016)
  • Author(s): 北村 淳, 野上晋之介, 山内健介, 田中謙光, 佐藤修一, 刀根武士, 及川麻理子, 清水良央, 熊本裕行, 高橋 哲
  • Journal Title: 東北大学歯学雑誌 Volume: 35 Pages: 1-1
  • Peer Reviewed
• [Journal Article] 過去15年間の当科における口蓋形成手術の臨床的検討（第1報）- 口蓋垂基部と咽頭後壁間距離の後ろ向き調査 (2016)
  • Author(s): 野上晋之介、松井桂子、君塚 哲、片岡良浩、山内健介、橋元 亘、越後成志、髙橋 哲
  • Journal Title: 東北大学歯学雑誌 Volume: 35 Pages: 1-1
  • Peer Reviewed
• [Journal Article] Facilitation of bone resorption activities in synovial lavage fluid patients with mandibular condyle fractures. (2016)
  • Author(s): Takano H, Takahashi T, Nakata A, Nogami S, Yusa K, Kuwajima S, Yamazaki M, Fukuda M
  • Journal Title: J Oral Rehabil Volume: 43 Issue: 5 Pages: 1-1
  • DOI: 10.1111/joor.12388
  • Peer Reviewed
• [Journal Article] Radicular cyst associated with anomalous tooth, suspicious of dens invaginatus: report of two cases (2016)
  • Author(s): Karaoke Y, Yamaguchi K, Saito M, Nogami S, Yamaguchi Y, Saito H, Kumamoto H, Takahashi T
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: 28 Pages: 1-1
  • Peer Reviewed