Predicting lymph node metastasis of tongue cancer with IVIM MR imaging

• Project/Area Number: 25861778
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SAKAMOTO Junichiro 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (40506896)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 画像診断 / 癌 / 臨床 / 拡散現象 / 灌流現象

Outline of Final Research Achievements

In this work, we evaluated the feasibility of IVIM for maxillofacial mass lesions preliminary for its application to the tongue cancer. Diffusion-weighted images of 33 patients with the tumors (10 benign and 23 malignant) in maxillofacial regions were evaluated. Using the IVIM technique, parameters (D, true diffusion coefficient; f, perfusion fraction; D*, pseudo-diffusion coefficient) were calculated for each lesion. ADC values were also measured, and IVIM parameters and ADC values in benign and malignant tumors were compared. We obtained the result that the technique of combining IVIM parameters (D and D*) could provide high accuracy for the predicting malignancy, in comparison with ADC.

Research Products

• [Journal Article] 特集アドバンストコース『臨床画像』2015年7月号特集 口腔外科・歯科領域の画像診断：放射線科医の日常臨床に役立つ知識 (2015)
  • Author(s): 坂本潤一郎
  • Journal Title: 臨床画像 Volume: 31 Pages: 1397-1399
• [Journal Article] Comparison of accuracy of intravoxel incoherent motion and apparent diffusion coefficient techniques for predicting malignancy of head and neck tumors using half-Fourier single-shot turbo spin-echo diffusion-weighted imaging. (2014)
  • Author(s): Sakamoto J, Imaizumi A, Sasaki Y, Kamio T, Wakoh M, Otonari-Yamamoto M, Sano T.
  • Journal Title: Magnetic Resonance Imaging Volume: 32 Issue: 7 Pages: 860-866
  • DOI: 10.1016/j.mri.2014.05.002
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 拡散尖度画像によるcystic componentを有する歯原性病変の診断能について (2015)
  • Author(s): 坂本潤一郎, 小滝真也, 藤倉満美子, 中村 伸, 栗林亜実, 倉林 亨
  • Organizer: 第51回日本医学放射線学会秋季臨床大会・第28回頭頸部放射線研究会
  • Place of Presentation: 盛岡市，マリオス・盛岡市民文化ホール
  • Year and Date: 2015-10-03
• [Presentation] Diffusion Kurtosis Imaging (DKI) による嚢胞または嚢胞性領域を有する歯原性病変の分析. (2015)
  • Author(s): 坂本潤一郎, 小滝真也, 新垣理宣, 栗林亜実, 倉林 亨.
  • Organizer: 日本歯科放射線学会第 56 回総会・学術大会
  • Place of Presentation: 仙台市，仙台市戦災復興記念館
  • Year and Date: 2015-06-06
• [Presentation] 頬粘膜に転移した乳癌の1例. (2014)
  • Author(s): 坂本潤一郎, 中村 伸, 栗林亜実, 鉄村明美, 鳥井原 彰，倉林 亨.
  • Organizer: 第50回日本医学放射線学会秋季臨床大会・第27回頭頸部放射線研究会
  • Place of Presentation: 神戸
  • Year and Date: 2014-09-27
• [Presentation] Intravoxel incoherent motion (IVIM) 解析による 頭頸部腫瘍の良悪性鑑別
  • Author(s): 坂本潤一郎，今泉晶子，佐々木秀憲，神尾 崇，和光 衛，音成実佳，倉林 亨，佐野 司
  • Organizer: 日本歯科放射線学会第54回総会・学術大会
  • Place of Presentation: 福岡市