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The elucidation of the effect of innate immune signaling on production of antimicrobial factors by salivary glands

Research Project

Project/Area Number 25861782
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionAsahi University

Principal Investigator

INOMATA Megumi  朝日大学, 歯学部, 助教 (40553798)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords口腔細菌 / 宿主応答 / Porphyromonas gingivalis / 抗菌性因子
Outline of Final Research Achievements

Antimicrobial factors produced from the salivary glands play an important role in maintaining homeostasis of the oral cavity. However, on the other hand, the mechanism of production of antimicrobial factors by salivary glands is not currently understood. Although salivary glands despite not subject to direct exposure of oral bacteria, what mechanisms is involved in production of antibacterial factors. In this study, the effects of oral bacteria on production of antibacterial factors by the salivary glands are investigated.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] リアルタイム定量PCRによる唾液からの口腔レンサ球菌種の検出2014

    • Author(s)
      猪俣 恵, 引頭 毅, 長谷川 義明, 村上 幸孝
    • Journal Title

      岐阜歯科学会雑誌

      Volume: 41(2) Pages: 73-78

    • NAID

      120005867884

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Porphyromonas gingivalis はOmpA様蛋白質を介して血管内皮細胞に付着し 細胞応答や細胞死を誘導する2014

    • Author(s)
      猪俣 恵、引頭 毅、稲葉 裕明、堀江 俊、北井 則行、村上 幸孝
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 唾液腺における抗体ならびに抗菌性タンパク質産生におけるシグナル伝達分子MyD88の役割の検討2014

    • Author(s)
      引頭 毅、猪俣 恵、稲葉 裕明、村上 幸孝
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tannerella forsythiaが有するOmpA様蛋白質の宿主細胞表層レクチンへの結合能の解析2014

    • Author(s)
      堀江 俊、猪俣 恵、出水川 雅司、稲葉 裕明、引頭 毅、北井 則行、村上 幸孝
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Porphyromonas gingivalisのMfa1線毛構築におけるMfa4の役割の解析2014

    • Author(s)
      長谷川義明、井貝亮太、出水川雅司、堀江俊、猪俣恵、北井則行、吉村文信、村上幸孝
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Porphyromonas gingivalisにおける蛋白質リン酸化の増殖への影響2014

    • Author(s)
      出水川雅司、井貝亮太、堀江俊、長谷川義明、猪俣恵、稲葉 裕明、引頭 毅、吉村文信、北井則行、村上幸孝
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 原理の異なる唾液検査キットのミュータンスレンサ球菌検出能の比較2014

    • Author(s)
      高橋 らら、高本 将司、落合 宏樹、猪俣 恵、稲葉 裕明、長谷川 義明、引頭 毅、村上 幸孝
    • Organizer
      第179回 岐阜歯科学会
    • Place of Presentation
      岐阜
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Porphyromonas gingivalisのOmpA様蛋白質は 細胞毒性および免疫応答の誘導に関与する2014

    • Author(s)
      猪俣 恵、長谷川 義明、村上 幸孝
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京都船堀
    • Related Report
      2013 Research-status Report
  • [Remarks] 朝日大学 口腔感染医療学講座 口腔微生物学分野

    • URL

      http://scw.asahi-u.ac.jp/~bac/index.html

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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