Creation of root caries model for evaluation and development of antibacterial biomaterials
| Project/Area Number |
25861784
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Mayanagi Gen 東北大学, 歯学研究科, 助教 (10451600)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ISFET微小pH電極 / pH / エナメル質 / 象牙質 / 根面う蝕 / う蝕関連細菌 / 脱灰 / インターフェイス / ISFET微小ｐH電極 / ｐH |
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| Outline of Final Research Achievements |
The mineral solubility of coronal enamel and root dentin were evaluated using a model of tooth/bacteria interface. The pH changes at the interface were measured by a miniature ion-sensitive field-effect transistor pH electrode and the amounts of calcium dissolved from tooth surfaces were measured by a fluorescent dye. As a result, it was suggested that root dentin is more soluble to the bacteria-induced acidification than coronal enamel, and that the minerals dissolved from tooth surfaces could raise pH at the tooth/bacteria interface. The method employed in the present study could be useful for evaluating the caries-preventive effects on tooth surface treatment.
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Report
(5 results)
Research Products
(29 results)
