| Project/Area Number |
25861802
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯髄炎 / 歯髄細胞 / 自然免疫 / インターフェロンγ / TLR / NOD / IL-6 / CXCL10 |
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| Outline of Final Research Achievements |
In the progression of pulpitis, marked infiltration of inflammatory cells such as activated T cells producing interferon-γ (IFN-γ) is observed. Dental pulp cells have a capacity to produce various pro-inflammatory cytokines in response to caries-related bacteria via microbial pattern recognition receptors (PRRs). It is possible that IFN-γ can modulate pro-inflammatory response to PRRs ligands on the dental pulp cells. Indoleamine 2, 3-dioxygenase (IDO) is a regulator of immune responses and has been implicated in the progression of tumor tolerance, autoimmune disease and asthma. Although IDO expression is regulated and induced by IFN-γ in immune cells, IDO expression in dental pulp cells have not been reported.
This study demonstrated the synergistic effects by IFN-γ on IL-6 and CXCL10 production and expression of IDO in cultured human dental pulp cells. These findings suggest that IFN-γ may modulate the innate immune response of human dental pulp cells.
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