| Project/Area Number |
25861819
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯科材料 / 抗酸化アミノ酸 / 直接覆髄 / 歯髄 / 象牙質再生 / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
This study tested whether N-acetyl cysteine (NAC), anti-oxidant amino acid derivative, could control the effect of dental materials on osteoblasts and dental pulp. NAC improve osteoblastic viability by application of N-acetyl cysteine with increased level of intracellular glutathione reserves. A rat model was used to examine the potential of NAC as a direct-pulp-capping agent. NAC containing-collagen sponge was placed onto the exposed pulp in maxillary first molar of 8 week-old Sprague-Dawley rats. Rats were sacrificed at 4 weeks post-operatively. Teeth were stained with hematoxylin-eosin and observed under a light microscopy. In vivo experiments, NAC induced reparative dentin. It was indicated that NAC induce dentin regeneration on dental material.
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