Evaluation of peri-implant bones generated by apatite crystal

• Project/Area Number: 25861822
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Tohoku University
• Principal Investigator: SHIRAISHI Naru 東北大学, 歯学研究科, 大学院非常勤講師 (60585355)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: インプラント / オッセオインテグレーション / インプラント周囲骨 / 生体アパタイト / 結晶配向性 / 表面性状

Outline of Final Research Achievements

Dental implants are widely used and are a predictable treatment in various edentulous cases. Occlusal overload may be causally related to implant bone loss and a loss of integration. Stress concentrations may be diminished using a mechanobiologically integrated implant with bone tissue. The purpose of this study was to investigate the biomechanical behavior, biocompatibility and bioactivity of a Ti-Nb-Sn alloy as a dental implant material. It was compared with cpTi. Cell proliferation and ALP activity in the cells grown on prepared surfaces were similar for the Ti-Nb-Sn alloy and for cpTi in all the experiments. A comparison between the Ti-Nb-Sn alloy implant and the cpTi implant revealed that no significantdifference was apparent for the push-in test values. These results suggest that implants fabricated using Ti-Nb-Sn have a similar biological potential as cpTi and are capable of excellent osseointegration.

Research Products

• [Journal Article] Biomechanical Evaluation of Ti-Nb-Sn Alloy Implants with a Low Young's Modulus. (2015)
  • Author(s): Takahashi K, Shiraishi N, Ishiko-Uzuka R, Anada T, Suzuki O, Masumoto H, Sasaki K.
  • Journal Title: Int J Mol Sci. Volume: 16 Issue: 3 Pages: 5779-5788
  • DOI: 10.3390/ijms16035779
  • Peer Reviewed / Open Access
• [Presentation] 低弾性高強度Ti-Nb-Sn合金のメカノバイオロジー (2014)
  • Author(s): 高橋健太，白石成，石河（宇塚）理紗，穴田貴久，鈴木治，増本博，佐々木啓一
  • Organizer: 歯科理工学会
  • Place of Presentation: アステールプラザ（広島県広島市）
  • Year and Date: 2014-10-04 – 2014-10-05
• [Presentation] Biomechanical Evaluation of Ti-Nb-Sn with Low Young’s Modulus (2014)
  • Author(s): Takahashi K, Shiraishi N, Ishiko-Uzuka R, Anada T, Sasaki K, Suzuki O, Masumoto H
  • Organizer: The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Japan