The association between primary sleep bruxism and polymorphisms or epigenetical regulations
| Project/Area Number |
25861833
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Showa University (2014-2015)
Tokyo Medical and Dental University (2013) |
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Principal Investigator |
Abe Yuka 昭和大学, 歯学部, 助教 (80614156)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 睡眠時ブラキシズム / SNP / 遺伝子多型 / セロトニン神経系 / PSG検査 / DNAメチル化 / SNPs / メチル化 |
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| Outline of Final Research Achievements |
The aim of study was to investigate the association between multifactorial primary sleep bruxism and polymorphisms or epigenetical regulations. A total of 29 individuals (F/M=16/13, mean age 26.4 ±2.8 y) participated after signing the university-approved consent form. Polysomnography and genotyping were conducted with these participants. The result showed that the individuals with rs6311 (-1438A/G) G allele in the promoter region of 5-HT 2A gene exhibited significantly more frequent tonic bursts during sleep (median: 1.43 times/hr, range 0-4.12, p=0.029). In order to approach serotonergic epigenetic regulation in the etiology of sleep bruxism, the animal study was performed. The experiment on mice suggested that selective serotonin uptake inhibitors (SSRIs) might affect the induced threshold level of masseter muscle activity during sleep.
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Report
(4 results)
Research Products
(13 results)
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[Presentation] Establishment of Human Sleep Bruxism Model by Induced Pluripotent Stem Cells(iPSCs).2015
Author(s)
Hoashi Y, Okamoto S , Matumoto T, Yoshida Y, Tanaka J, Imaizumi K, Abe Y, Akamatu W, Okano H, Mishima K, Baba K
Organizer
4th Asian Academic Congress for Temporomandibular Joint
Place of Presentation
Manila, Philippine
Year and Date
2015-11-16
Related Report
Int'l Joint Research
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[Presentation] The effects of citalopram on masseter and neck muscle activities in mice2015
Author(s)
Nogawa Y, Mochizuki A, Katayama K, Ikeda M, Abe Y, Nakamura S, Nakayama K, Kiyomoto M, Kato T, Baba K, Wakabayashi N, Inoue T
Organizer
Society for Neuroscience 2015 Annual Meeting
Place of Presentation
Chicago, USA
Year and Date
2015-09-17
Related Report
Int'l Joint Research
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[Presentation] Serotonin receptor gene polymorphism in sleep bruxism: a polysomnographic study.2015
Author(s)
Abe Y, Hoashi Y, Yoshida Y, Yoshizawa S, Sakai T, Suganuma T, Takaba M, Ono Y, Yoshizawa A, Nakamura H, Kawana F, Baba K
Organizer
16th Biennial Meeting of the International College of Prosthodontists
Place of Presentation
Seoul, South Korea
Year and Date
2015-09-17
Related Report
Int'l Joint Research
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[Presentation] 閉塞性睡眠時無呼吸症候群患者における口腔内装置装着に伴う顎顔面・上部気道形態の変化が治療結果に与える影響2014
Author(s)
小海暁, 犬飼周佑, 酒井敬一, 中村周平, 桐井絢子, 上杉俊輔, 三間裕子, 安部友佳, 上里彰仁, 藤江俊秀, 西山暁, 玉岡明洋, 宮崎泰成, 秀島雅之, 小野卓史
Organizer
日本睡眠学会第39回定期学術集会
Place of Presentation
徳島
Year and Date
2014-07-03 – 2014-07-04
Related Report
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