| Project/Area Number |
25861845
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Hiroshima University |
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Principal Investigator |
MORITA Koji 広島大学, 大学病院, 助教 (30555149)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ポリリン酸 / 骨再生 / 表面形状 / アパタイト |
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| Outline of Final Research Achievements |
This study was designed to elucidate the effect of HA plate adsorbed with PolyP-65 on proliferation or differentiation of MC3T3-E1 cells. After we confirmed adsorption of PolyP-65 onto the surface of HA plate, Surface roughness, water contact angle of HA plate adsorbed with PolyP-65, and calcium deposition and osteoblast differentiation in MC3T3-E1 culture were evaluated. Within the limited results of this study, it may be concluded that HA plate adsorbed with PolyP-65 at high concentration enhances calcification by binding calcium ion from medium, promoting differentiation of MC3T3-E1 cells.
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