Enhancement of tissue integration with calcium-hydrothermal treatment

• Project/Area Number: 25861854
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Kyushu University
• Principal Investigator: FURUHASHI AKIHIRO 九州大学, 大学病院, 医員 (60608975)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 歯科インプラント / カルシウム水熱処理

Outline of Final Research Achievements

One of the important factors for the long time stability of dental implant is biocompatibility. In this study, we focused on the Calcium-Hydrothermal treatment (Ca-HT) for its effect on promoting tissue integration. Calcium modification onto titanium was observed without changing surface roughness. In in vitro study, cell adhesion strength was increased in Ca-HT group. In in vivo study, broader expression of adhesion structure between epithelium and implant was observed. These findings suggest that stronger tissue integration would be formed around Ca-HT titanium.

Research Products

• [Journal Article] Promoting effect of CaCl2 hydrothermal treatment to titanium implant surface for early epithelial sealing (2015)
  • Author(s): Oshiro W, Ayukawa Y, Atsuta I, Furuhashi A, Yamazoe J, Kondo R, Sakaguchi M, Matsuura Y, Tsukiyama Y, Koyano K
  • Journal Title: Colloids and Surfaces B Volume: -
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Therapeutic Interaction of Systemically-administered Mesenchymal Stem Cells with Peri-implant Mucosa (2014)
  • Author(s): Ryosuke KONDO, Ikiru ATSUTA, Yasunori AYUKAWA, Takayoshi YAMAZA, Yuri MATSUURA, Akihiro FURUHASHI, Yoshihiro TSUKIYAMA, Kiyoshi KOYANO
  • Journal Title: PLoS One Volume: 9(3) Issue: 3 Pages: e90681-e90681
  • DOI: 10.1371/journal.pone.0090681
  • Peer Reviewed / Open Access
• [Journal Article] Micro-CT and histomorphometric analyses of novel titanium mesh membranes for guided bone regeneration: A study on rat calvarial defects (2014)
  • Author(s): Rakhmatia YD, Ayukawa Y, Furuhashi A, Koyano K
  • Journal Title: Int J Oral Maxillofac Implants Volume: 29 Pages: 826-835
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fibroblast attachment onto novel titanium mesh membranes for guided bone regeneration (2014)
  • Author(s): Rakhmatia YD, Ayukawa Y, Atsuta I, Furuhashi A, Koyano K
  • Journal Title: Odontology Volume: - Issue: 2 Pages: 2180226-2180226
  • DOI: 10.1007/s10266-014-0151-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] The Facilitatory Effect of Calcium-hydrothermal Treatment on Peri-implant Epithelial Sealing (2015)
  • Author(s): Oshiro W, Ayukawa Y, Atsuta I, Kondo R, Furuhashi A, Koyano K
  • Organizer: The 93rd IADR General Session & Exhibition
  • Place of Presentation: アメリカ、ボストン
  • Year and Date: 2015-03-11 – 2015-03-14
• [Presentation] Accelerated healing of extraction socket and peri-implant tissue by statin (2015)
  • Author(s): Noriyuku Yasunami, Yasunori Ayukawa, Akihiro Furuhashi, Ikiru Atsuta, Rakhmatia Yunia Dwi, Yasuko Moriyama, Kiyoshi Koyano
  • Organizer: The 93rd International Association for Dental Research
  • Place of Presentation: アメリカ、ボストン
  • Year and Date: 2015-03-11 – 2015-03-14
• [Presentation] A Solution for Rehabilitation of Angle-Class2 Patient: A Case Report (2014)
  • Author(s): Furuhashi A, Ayukawa Y, Atsuta I, Koyano K.
  • Organizer: 38th annual conference of the European Prosthodontic Association
  • Place of Presentation: トルコ、イスタンブール
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] チタンに対する上皮封鎖性向上法の探求–塩化カルシウム水熱処理の効果− (2014)
  • Author(s): 大城和可奈，鮎川保則，熱田生，古橋明大，古谷野潔
  • Organizer: 第44回公益社団法人日本口腔インプラント学会学術大会
  • Place of Presentation: 東京都、東京国際フォーラム
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] Promoting effect of CaCl2 hydrothermal treatment to titanium implant surface on epithelial sealing (2014)
  • Author(s): Wakana Oshiro, Ikiru Atsuta, Yasunori Ayukawa, Ryosuke Kondo, Akihiro Furuhashi, Kiyoshi Koyano
  • Organizer: 9th International Workshop on Biomaterials in Interface Science
  • Place of Presentation: 宮城県、蔵王、宮城蔵王ロイヤルホテル
  • Year and Date: 2014-08-26 – 2014-08-27
• [Presentation] チタンのカルシウム水熱処理 (2014)
  • Author(s): 大城和可奈，鮎川保則，熱田生，古橋明大，近藤綾介，坂口真実，古谷野潔
  • Organizer: 公益社団法人日本補綴歯科学会第123回学術大会
  • Place of Presentation: 仙台市、仙台国際センター
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] Mesenchymal stem cells promote soft tissue sealing around titanium implants (2014)
  • Author(s): Atsuta I, Ayukawa Y, Kondo R, Matsuura Y, Furuhashi A, Takahashi A, Koyano K
  • Organizer: 86th Annual Meeting of the American Prosthodontic Society
  • Place of Presentation: アメリカ、シカゴ
• [Presentation] Promoting effect of CaCl2 hydrothermal treatment to titaniumimplant surface for epithelial sealing (2014)
  • Author(s): Wakana Oshiro, Ikiru Atsuta, Yasunori Ayukawa, Jyunichi Yamazoe, Ryosuke Kondo, Mami Sakaguti, Akihiro Furuhashi, Kiyoshi Koyano
  • Organizer: 86th Annual Meeting of the American Prosthodontic Society
  • Place of Presentation: アメリカ、シカゴ
• [Presentation] Prosthodontictic rehabilitation of a patient with partial anodontia – a case report. (2013)
  • Author(s): Furuhashi A, Ayukawa Y, Sasaki M, Matsushita Y, Atsuta I, Koyano K
  • Organizer: 15th biannual meeting of International Collage of Prosthodontics, Turin, September, 2013
  • Place of Presentation: イタリア、トリノ
• [Presentation] Evaluation of biodegradable polymer-calcium phosphate nanoparticle composite as a bone substitute material. (2013)
  • Author(s): Shimizu H, Jinno Y, Ayukawa Y, Atsuta I, Furuhashi A, Koyano K
  • Organizer: 2013 Biennial Joint Congress of CPS-JPS-KAP
  • Place of Presentation: 韓国、済州島
• [Presentation] Effect of fluvastatin on proliferation and migration of fibroblast. (2013)
  • Author(s): Yasunami N, Ayukawa Y, Furuhashi A, Atuta I, Koyano K
  • Organizer: 2013 Biennial Joint Congress of CPS-JPS-KAP
  • Place of Presentation: 韓国、済州島
• [Presentation] Injection timing of Mesenchymal Stem Cells to promote the soft tissue sealing around titanium implant. (2013)
  • Author(s): Atsuta I, Ayukawa Y, Kondo R, Furuhashi A, Matsuura Y, TsukiyamaY, Koyano K
  • Organizer: Biennial Joint Congress of CPS-JPS-KAP
  • Place of Presentation: 韓国、済州島
• [Presentation] Enhanced Soft Tissue Integration around Hydrothermal Calcium-Treated Dental Implants (2013)
  • Author(s): Furuhash A, Ayukawa Y, Atsuta I, Rakhmatia YD, Oshiro W, Yasunami N, Haraguchi T, Kondo R, Sakaguchi M, Koyano K
  • Organizer: 平成25年度日本歯科理工学会九州支部夏期セミナー
  • Place of Presentation: 長崎