Study on effect of mastication for prevention of diabetes via GLP-1
Project/Area Number |
25861860
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Prosthodontics/ Dental materials science and
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Research Institution | Health Sciences University of Hokkaido |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 咀嚼 / GLP-1 / 糖代謝 / 咬合 / 糖尿病 / 生活習慣病 |
Outline of Final Research Achievements |
GLP-1 is synthesized in the intestine and has a function called incretin effect to lower levels of glucose in the blood. In this study, I built the hypothesis that mastication promotes GLP-1 by parasympathetic nerve, and we examined mastication affect secretion of GLP-1 and number of pancreatic beta-cells. Active GLP-1 levels in rats that masticated solid feed, was higher than that in the rats that drank liquid feed. In case of intraperitoneal administration of atropine to block parasympathetic nerve , GLP-1 level in the both groups were approximately equal level. After breeding by solid feed or liquid feed for 3 months, pancreatic beta-cells in the solid feed group were observed more than that in the liquid feed group. In this study, it is suggests that mastication affects the secretion of GLP-1 via parasympathetic nerve and GLP-1 protects pancreatic beta-cells in rats.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] The effect of mastication for glycometabolism2015
Author(s)
Toyoshita Y., Kan Y., Sasaki M,. Kawanishi K., Aita H., Koshino H.
Organizer
93th General Session & Exhibition of the IADR
Place of Presentation
John B. Hynes Veterans Memorial Convention Center(アメリカ合衆国マサチューセッツ州ボストン)
Year and Date
2015-03-11 – 2015-03-14
Related Report
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[Presentation] The effect of mastication on glp-1 via parasympathetic nerve2014
Author(s)
Kan Y, Toyoshita Y, Kawanishi K, Aita H, Koshino H.
Organizer
38th Annual Conference of the European Prosthodontic Association & 21st Scientific Congress of the Turkish Prosthodontic and Implantology Association
Place of Presentation
Istabul Karamis Marina Hotel (トルコ共和国 イスタンブール)
Year and Date
2014-09-25 – 2014-09-27
Related Report
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