| Project/Area Number |
25861873
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Research Collaborator |
ISONO Kazushige 松本歯科大学, 歯学部, 助手 (10646590)
MITSUI Tatsuhisa 松本歯科大学, 歯学部, 助手
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 睡眠 / 血圧 / ブラキシズム / 交感神経活動 / 圧受容器反射 / 低酸素 / 睡眠ブラキシズム / 圧反射 / 昇圧反応 / 交感神経活動測定 / 連続血圧測定 |
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| Outline of Final Research Achievements |
Blood pressure (BP) decreases during sleep and the lack of the reduction is associated with cardiovascular events. Sleep bruxism evokes an increase in heart rate (HR) and may be one of the causes of nocturnal hypertension. We continuously measured beat-by-beat BP and sympathetic nerve activity (SNA) during sleep including bruxism period, and found that decreased BP and SNA during sleep were increased and increased R-R interval (RRI) and parasympathetic nerve activity (PSNA) were decreased by bruxism. The changes in BP and RRI were observed immediately before bruxism and those in SNA and PSNA were observed ~2o sec before bruxism. Cardiac baroreflex sensitivity (BRS) increased during sleep or sedation, but it was decreased by sleep bruxism or pain stimulation. On the other hand, sympathetic BRS remained unchanged in neither condition. Furthermore, bruxism frequency during sleep in hypoxia was higher than that in normoxia.
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