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The development of new bone augmentation technique with 4-META/MMA-TBB resin containing calcium carbonate and collagen sponge impregnated BMP-2

Research Project

Project/Area Number 25861878
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionHokkaido University

Principal Investigator

Nakatsuka Megumi  北海道大学, 大学病院, 助教 (00547648)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords4-META/MMA-TBBレジン / 生体活性材料 / 複合化レジン / 骨増生 / BMP-2 / 炭酸カルシウム / TCP / 硬組織誘導
Outline of Final Research Achievements

We evaluated bone formation and direct contact ratio following BMP application on 4-META/MMA-TBB resin containing calcium carbonate or αTCP on skull of rats.As a result,this technique can induce bone growth covering entire surface of the resin and increase the direct contact ratio between the resin and new bone.Furthermore,we observed that new bone was formed covering entire surface of the resin containing calcium carbonate or α-TCP on bone defect of wide range of buccal alveolar bone of beegle dogs following BMP application on the composite resin.
From these results,it was suggested that this technique can regenerate bone quickly for wide range and complex shaped bone defects and recover the bone form freely.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2015 2013

All Presentation (3 results)

  • [Presentation] カルシウムを混和した4-META/MMA-TBBレジン上への新生骨の接触2015

    • Author(s)
      柳澤 剛、菅谷 勉、中塚 愛、川浪雅光
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      北九州国際会議場(福岡県北九州市)
    • Year and Date
      2015-06-25 – 2015-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] カルシウムを混和した4-META/MMA-TBBレジン上への新生骨の接触2015

    • Author(s)
      柳澤 剛、菅谷 勉、工藤(中塚) 愛、佐藤賢人、猪股慶久、川浪雅光
    • Organizer
      第142回春季日本歯科保存学会
    • Place of Presentation
      北九州国際会議場(福岡県北九州市)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] カルシウムを混和した4-META/MMA-TBBレジン上への骨形成2013

    • Author(s)
      柳澤 剛、菅谷 勉、中塚 愛、川浪雅光
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      秋田県総合生活文化会館(秋田県秋田市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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