| Project/Area Number |
25861882
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Noritake Kanako 東京医科歯科大学, 歯学部附属病院, 助教 (60624210)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨造成 / GBR / 吸収性メンブレン / FGF-2 / FGF-18 / 骨膜 / ラット / 頭蓋骨 / 垂直的骨造成 |
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| Outline of Final Research Achievements |
A basic study for development of a novel bone graft technique which is effective not only bone neogenesis but also preventing mucosa dehiscence by utilizing rhFGF-2, which is effective for mucosa hyperplasty, impregnated GBR membrane installed at the surgical site. We also investigated the utility of FGF-18 and membrane combination because of it’s profitably to bone formation. First, the biocompatibility and its validity as a GBR membrane of improved gelatin hydrogel membrane containing β-tricalcium phosphate (G/T) was confirmed. Then, rhFGF-2 or rhFGF-18 impregnated G/Ts were installed between rat parietal bone or with silicon dome and the above periosteum to determine their effect to mucosa healing and bone neogenesis. Well-mucosa healing was observed at surgical site and newly-formed bone was observed at the space created by the G/T worked as a space keeper while worked as the carrier of FGFs.
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