Bone regeneration by periosteal elevation using conventional orthodontic wire and uHA/PLLA mesh

• Project/Area Number: 25861883
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: University of Yamanashi
• Principal Investigator: SOTOBORI Megumi 山梨大学, 医学部附属病院, 医員 (10646607)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 骨膜伸展 / 持続的伸展力 / 矯正用ワイヤー / 新生骨面積 / 抗BMP-2抗体陽性細胞 / 抗BMP-2 抗体陽性細胞

Outline of Final Research Achievements

This study evaluated bone regeneration by periosteal elevation using conventional orthodontic wire and an absorbable mesh in rabbit nasal bone. In the experimental group, 1 week after the mesh was inserted under the periosteal membrane, it was elevated by traction using the mesh connected with wire and two anchor screws. In the control group, the mesh was kept inserted under the periosteal membrane. Four animals were killed in each period in both groups, at 2, 3, 5 and 9 weeks postoperatively. Operated parts were removed and prepared for histological assessment. The bone area and the expression of BMP-2 were evaluated, and these value in the experimental group was significantly increased　more than that in the control group in the time-course change (bone area P<0.0010, BMP-2 P=0.0015). This study suggests that bone regeneration can be induced by periosteal elevation using a conventional orthodontic wire and an absorbable mesh.

Research Products

• [Journal Article] Bone regeneration by periosteal elevation using conventional orthodontic wire and uHA/PLLA mesh. (2014)
  • Author(s): Sotobori M, Ueki K, Ishihara Y, Moroi A, Marukawa K, Nakazawa R, Higuchi M, Iguchi R, Ikawa H, Kosaka A.
  • Journal Title: J Craniomaxillofac Surg Volume: 42(8) Pages: 1742-7
  • Peer Reviewed / Open Access
• [Presentation] Periosteal expansion using orthodontic wire and mesh (2013)
  • Author(s): Megumi Sotobori, Koichiro Ueki, Kohei Marukawa, Akinori Moroi, Yuri Ishihara, Ran Iguchi, Akihiko Kosaka, Hiroumi Ikawa, Yoshio Nakano, Masatoshi Higuchi, Ryuichi Nakazawa
  • Organizer: The 2nd Meeting of International Association of Dental Research- Asia Pacific Region
  • Place of Presentation: Bangkok, Thailand