| Project/Area Number |
25861898
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ジルコニア / 抗菌ペプチド / 機能性人工タンパク質 / Lactoferricin / histatin5 |
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| Outline of Final Research Achievements |
Two functional artificial peptide were synthesized chemically by the fusion with Histatin 5 or Lactoferricin peptide motif, known as antimicrobial peptide, and Zirconia binding peptide motif. These peptides dissolved in solvents were coated on the surface of Zirconia disc, and then, P. gingivalis, well-known as periodontopathic bacterium, was incubated for two days at 37°C under aerobic condition. Subsequently, the activity of these peptides was evaluated with determination of viable bacteria count. The viable bacteria count in theses peptides were reduced gradually in a concentration dependent manner of peptide. From the result, it suggested that two novel functional artificial peptides have antimicrobial activity against a P gingivalis.
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