Basic research for periodontal tissue regeneration type implant using periodontal ligament cells
| Project/Area Number |
25861901
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯周組織再生 / 歯根膜 / 象牙質 / 歯槽骨 / セメント質 / インプラント / 象牙芽細胞 / 歯髄 / アパタイトコーティング |
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| Outline of Final Research Achievements |
The purpose of this research was verifying the possibility of the periodontal ligament regeneration around the tooth implant.
In this study I revealed the following. (1) The ceria-stabilized tetragonal zirconia polycrystals/ aluminium oxide nanocomposite (Ce-TZP) has a same ability for bone induction compared to titanium. (2) In transplantation experiments of titanium implants to type 2 diabetes model rat. Nerve growth factor (NGF) was effective for bone induction to surrounding the implant. (3) The different of the two splice variants of porcine dentin sialophosphoprotein (DSPP) gene were revealed between dental pulp cells and odontoblasts. From this result, it showed that DSPP gene is useful as a differentiation marker of odontoblasts.
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Report
(3 results)
Research Products
(5 results)
