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The study on RIG-I and cancer associated fibroblast function for the regulation of mucositis induced by chemotherapy

Research Project

Project/Area Number 25861907
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionHirosaki University

Principal Investigator

KUBOTA Kosei  弘前大学, 医学部附属病院, 助教 (10529689)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords歯学 / 遺伝子 / 口腔粘膜炎
Outline of Final Research Achievements

The purpose of this study was to establish new therapy of oral mucositis induced by chemotherapy. The model of cancer associated fibroblast was built out and stimulated with docetaxel, LPS and poly IC, and examined the expression of RIG-I, innate immune system related gene and inflammatory cytokines mRNA. The cDNA microarray was performed. The comparison between fibroblast and cancer associated fibroblast indicated difference of innate immune systems. The expression of TLR -3 and -4 was decreased in cancer associated fibroblast compared to fibroblast, whereas the expression of RIG-I was increased. RIG-I in cancer associated fibroblast may have some roles in pathogenesis of oral mucositis induced by chemotherapy

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2015

All Presentation (2 results)

  • [Presentation] がん関連線維芽細胞と正常歯肉線維芽細胞の初期免疫応答能に関する比較検討2015

    • Author(s)
      久保田 耕世、伊藤 良平、古舘 健、中川 祥、榊 宏剛、小林 恒、木村 博人
    • Organizer
      日本口腔科学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-05-13 – 2015-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 正常歯肉線維芽細胞とがん関連線維芽細胞の比較検討2015

    • Author(s)
      久保田 耕世、中川 祥、今 敬生、小林 恒、木村 博人
    • Organizer
      口腔腫瘍学会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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