The study on RIG-I and cancer associated fibroblast function for the regulation of mucositis induced by chemotherapy

Research Project

Project/Area Number	25861907
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Hirosaki University
Principal Investigator	KUBOTA Kosei 弘前大学, 医学部附属病院, 助教 (10529689)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	歯学 / 遺伝子 / 口腔粘膜炎
Outline of Final Research Achievements	The purpose of this study was to establish new therapy of oral mucositis induced by chemotherapy. The model of cancer associated fibroblast was built out and stimulated with docetaxel, LPS and poly IC, and examined the expression of RIG-I, innate immune system related gene and inflammatory cytokines mRNA. The cDNA microarray was performed. The comparison between fibroblast and cancer associated fibroblast indicated difference of innate immune systems. The expression of TLR -3 and -4 was decreased in cancer associated fibroblast compared to fibroblast, whereas the expression of RIG-I was increased. RIG-I in cancer associated fibroblast may have some roles in pathogenesis of oral mucositis induced by chemotherapy

Report

(3 results)