Establishment of the pain control method by molecular delivery using ultrasound and nanobubbles

Research Project

Project/Area Number	25861908
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Tohoku University
Principal Investigator	MATOBA ATSUKO 東北大学, 歯学研究科(研究院), 助教 (70547257)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	術後疼痛制御 / ナノバブル / 分子デリバリー / GDNF
Outline of Final Research Achievements	Introduction of GDNF plasmid using nanobubbles and ultrasound into plantar muscle in postoperative pain model rat with plantar incision influence guarding behavior and heat/mechanical hyperalgesia. Analgesic effects are observed. However expression of pain-related cytokines and apoptosis of nerve cells are not changed. Further research will be necessary.

Report

(4 results)