| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
1. It has recently been reported that cancer stem cells (CSCs) is responsible for tumorigenesis, invasion, metstasis and chemo-radio resistance. We confirmed the increasing number of CSCs according to sphere formation in conditioned serum-free culture medium with epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF).
2. COX-2 was expressed in oral tumors, and significant positive correlation was found between Ki-67 and COX-2 expressions. It may contribute to local extensions
by increasing the proliferations of their odontogenic epithelial cells.
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