Molecular mechanism of cancer stem cells to chemoradio resistance in human oral squamous cell carcinoma
| Project/Area Number |
25861909
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Taniguchi Takahiro 東北大学, 歯学研究科(研究院), 大学院非常勤講師 (40444012)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYASHITA Hitoshi 東北大学, 大学院歯学研究科, 助教 (70372323)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 癌幹細胞 / 扁平上皮癌 / 口腔腫瘍 / 口腔扁平上皮癌 |
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| Outline of Final Research Achievements |
1. It has recently been reported that cancer stem cells (CSCs) is responsible for tumorigenesis, invasion, metstasis and chemo-radio resistance. We confirmed the increasing number of CSCs according to sphere formation in conditioned serum-free culture medium with epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF).
2. COX-2 was expressed in oral tumors, and significant positive correlation was found between Ki-67 and COX-2 expressions. It may contribute to local extensions
by increasing the proliferations of their odontogenic epithelial cells.
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Report
(4 results)
Research Products
(2 results)
