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Bisphosphonates related osteonecrosis: Aim to elucidate and treatment mechanism

Research Project

Project/Area Number 25861910
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTohoku University

Principal Investigator

Oizumi Takefumi  東北大学, 歯学研究科(研究院), 大学院非常勤講師 (40547262)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords顎骨壊死 / ビスフォスフォネート
Outline of Final Research Achievements

Bisphosphonates(BPs) agent with strong bone resorption inhibitory effect have been used for various enhanced bone-resorptive diseases. However, since BP-related osteonecrosis of the jaw (BRONJ), first reported in 2003, is increasing, with few effective strategies. BRONJ is exclusively associated with the use of nitrogen-containing BPs (NBPs). We previously reported that in mice, the non-NBP etidronate can reduce the inflammatory/necrotic effects of NBPs by inhibiting their intracellular entry and antagonize NBPs’ binding to bone hydroxyapatite absorption. We applied papers that the BRONJ 14 patients case and BRONJ patient of diabetes control bad case which tried to etidronate substitute replacement therapy of non-NBP.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] In vitro cytotoxicity of zoledronate (nitrogen-containing bisphosphonate: NBP) and/or etidronate (non-NBP) in tumourcells and periodontal cells2013

    • Author(s)
      Takefumi Oizumi
    • Journal Title

      Arch Oral Biol

      Volume: 58(6) Issue: 6 Pages: 628-37

    • DOI

      10.1016/j.archoralbio.2012.11.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Phosphate Transporters Ameliorates the Inflammatory and Necrotic Side Effects of the Nitrogen-Containing Bisphosphonate Zoledronate in Mice2013

    • Author(s)
      Satoru Okada, Tomomi Kiyama, Eri Sato, Yukinori Tanaka, Takefumi Oizumi, Toshinobu Kuroishi, Tetsu Takahashi, Keiichi Sasaki, Shunji Sugawara, Yasuo Endo.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 231 Issue: 2 Pages: 145-158

    • DOI

      10.1620/tjem.231.145

    • NAID

      130004822384

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] BRONJに対するダイドロネルへの置換療法2015

    • Author(s)
      大泉丈史
    • Organizer
      第3回宮城県口腔外科研究会
    • Place of Presentation
      東北大学歯学部(仙台)
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] BRONJ (bisphosphonate-related osteonecrosis of the jaw) の治療:etidronate 置換療法の試み2015

    • Author(s)
      大泉丈史
    • Organizer
      第36回東北骨代謝研究会
    • Place of Presentation
      江陽グランドホテル(仙台)
    • Year and Date
      2015-02-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 窒素含有 bisphosphonates (N-BPs) 治療患者での顎骨壊死:N-BPsのetidronate (non-N-BP) への置換の試み2014

    • Author(s)
      大泉丈史
    • Organizer
      第56回歯科基礎医学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 窒素含有 bisphosphonates(N-BPs)の炎症壊死作用:LPS による増強2014

    • Author(s)
      ○鈴木 飛佳理,大泉丈史
    • Organizer
      第56回歯科基礎医学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Zoledronate の軟組織細胞への取り込み:リン酸transporter関与の可能性.2013

    • Author(s)
      岡田諭,木山朋美,大泉丈史,佐々木啓一,高橋 哲,菅原俊二,遠藤康男
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      岡山,岡山コンベンションセンター
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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