| Project/Area Number |
25861915
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Toho University (2014-2015)
Tokyo Medical and Dental University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 口腔癌 / 原発巣 / 頸部リンパ節転移巣 / 相同性 / 相違性 / SNPsアレイ / 頸部リンパ節転移転移巣 / ゲノム / ＳＮＰｓアレイ / 頸部リンパ節転移 / ＳＮＰsアレイ / 転移時間 |
|---|
| Outline of Final Research Achievements |
We compared the genetic profile of paired primary tumor (PT) and metastatic lymph node (MLN) samples obtained from patients with oral tongue squamous cell carcinoma (OTSCC). Large-scale genetic profiling was performed on paired PT-MLN samples obtained from 10 OTSCC patients using high-density single-nucleotide polymorphism microarrays. We compared the genetic profile of PT and MLN OTSCC samples to identify common and specific copy number alterations (CNAs) and copy-neutral loss-of-heterozygosity (CN-LOH). This study indicates that additional genetic changes, such as 20q11.2 gain, which encodes the E2F1 gene, can be acquired through clonal evolution, and may be required for the metastatic process.
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