| Project/Area Number |
25861917
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HIGUCHI YUSUKE 東京医科歯科大学, 歯学部附属病院, 医員 (20635536)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 骨延長 / メンブレン / FGF-2 / 骨髄幹細胞 / 吸収性人工骨 |
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| Outline of Final Research Achievements |
This study was designed to evaluate the effect of drug controlled release-related living body absorption membrane and FGF-2, marrow stem in rabbit mandibular distraction. Peripheral quantitative computed tomographic analysis, von Kossa staining, and calcein staining showed significantly increased cortical bone mineraldensity, also had a significantly larger number of cells and radiopaque areas were observed morefrequently. The present findings suggested that the combined use of drug controlled release-related living body absorption membrane and FGF-2, marrow stem cells reduced the treatment period for distraction osteogenesis and accelerated the formation of a new high-quality bone.
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