| Project/Area Number |
25861920
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 口腔粘膜上皮内癌 / 血管 / リンパ管 / 粘膜固有層 / 線維化 / 口腔癌 / 上皮内癌 / 異型上皮 / 初期浸潤癌 / 癌間質 |
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| Outline of Final Research Achievements |
To evaluate the possibility of tumor stroma in lamina propriae of carcinoma in situ (CIS), the distribution of lymphatics and blood vessels, oral submucous fibrosis, the expression of extracellular matrix were investigated in CIS, normal epithelium, epithelial dysplasia and squamous cell carcinoma (SCC). Lymphatics in CIS were characterized by their closed lumen, irregular shapes. The distribution mode of closed and irregular shaped lymphatics in the peripheral invasive front of SCC resembled those of CIS. In CIS, the elastic fiber were irregularly formed and aggregated, and muscle fiber were denatured sporadically with slightly immunopositive stain due to the submucous fibrosis.
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