| Project/Area Number |
25861923
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔扁平上皮癌 / E-cadherin / 上皮間葉移行 / β-catenin |
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| Outline of Final Research Achievements |
Invasion and the metastasis of cancer are the most important characteristics, and it is thought that it controls prognosis to prevent the invasion of cancer. Therefore I focus attention on the decrease of the adhesion function between the cancer cell for an initial stage of the invasion, and epithelial-mesenchymal transition (EMT). In our previous studies, increace of migration and invasion ability was recognized by knockdown of E-cadherin. Thus we results to be considered altered expression of beta-catenin that binds to E-cadherin, increased in the nucleus was observed. Then, I examined relations with EMT by the malignancy. As a result of having examined expression of protein and RNA with the cell which a malignancy resisted, I recognized the tendency that EMT was acquired with the strong cell of the malignancy.
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