An examination about the effect of promotion in healing after orthognathic surgery by mechanical stimulation

• Project/Area Number: 25861924
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: University of Yamanashi
• Principal Investigator: MARUKAWA Kohei 山梨大学, 総合研究部, 医学研究員 (50444203)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 顎顔面外科 / 顎顔面骨 / 顎変形症 / 顎矯正手術 / 力学刺激 / 骨再生

Outline of Final Research Achievements

This experimental study was carried out using facial bone of rabbit, in order to examine about the effect of promotion in bone healing and in adaptation of temporomandibular joint, by mechanical stimulation using low-intensity pulsed ultrasound (LIPUS) after orthognathic surgery. Consequently, the result suggested that LIPUS promote the bone healing and the restoration of articular cartilage, particularly at postoperative early time. Therefore, it was thought that it was possible to shorten postoperative healing period.

Research Products

• [Journal Article] Changes in occlusal function after orthognathic surgery in mandibular prognathism with and without asymmetry. (2015)
  • Author(s): Moroi A, Ishihara Y, Sotobori M, Iguchi R, Kosaka A, Ikawa H, Yoshizawa K, Marukawa K, Ueki K.
  • Journal Title: Int J Oral Maxillofac Surg Volume: 44 Issue: 8 Pages: 971-976
  • DOI: 10.1016/j.ijom.2015.03.015
  • Peer Reviewed
• [Journal Article] Bone regeneration by periosteal elevation using conventional orthodontic wire and uHA/PLLA mesh (2014)
  • Author(s): Sotobori M, Ueki K, Ishihara Y, Moroi A, Marukawa K, Nakazawa R, Higuchi M, Iguchi R, Ikawa H, Kosaka A.
  • Journal Title: J Craniomaxillofac Surg Volume: 42 Issue: 8 Pages: 1742-1747
  • DOI: 10.1016/j.jcms.2014.06.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bone regeneration by statin and low-intensity pulsed ultrasound (LIPUS) in rabbit nasal bone (2014)
  • Author(s): Ishihara Y, Ueki K, Sotobori M, Marukawa K, Moroi A
  • Journal Title: J Craniomaxillofac Surg Volume: 42 Issue: 3 Pages: 185-193
  • DOI: 10.1016/j.jcms.2013.05.002
  • Peer Reviewed
• [Journal Article] Comparison between unsintered hydroxyapatite/poly-L-lactic acid mesh and titanium mesh in bone regeneration of rabbit mandible. (2013)
  • Author(s): Moroi A, Ueki K, Okabe K, Marukawa K, Sotobori M, Mukozawa A, Miyazakia M.
  • Journal Title: Implant Dent Volume: 22 Issue: 3 Pages: 255-262
  • DOI: 10.1097/id.0b013e31828336be
  • Peer Reviewed
• [Presentation] CT画像による下顎枝矢状分割術後の異なる固定法での骨性治癒の検討 (2014)
  • Author(s): 石原由梨、井川浩海、井口蘭、河阪明彦、外堀恵、諸井明徳、吉澤邦夫、丸川浩平、上木耕一郎
  • Organizer: 第59回日本口腔外科学会総会・学術大会
  • Place of Presentation: 幕張メッセ（千葉県千葉市）
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] Changes in occlusal function after orthognathic surgery in mandibular prognathism with and without asymmetry (2014)
  • Author(s): Moroi A, Ishihara Y, Sotobori M, Iguchi R, Kosaka A, Ikawa H, Nakazawa R, Higuchi M, Marukawa K
  • Organizer: XXII congress of the European association for cranio-maxillofacial surgery
  • Place of Presentation: プラハ（チェコ共和国）
  • Year and Date: 2014-09-23 – 2014-09-26
• [Presentation] Clinical study of the cases of surgically treated jaw deformity with molar defects combined with dental implant treatment. (2014)
  • Author(s): Kohei Marukawa, Akinori Moroi, Megumi Sotobori , Yuri Ishihara, Akihiko Kosaka, Ran Iguchi, Hiroumi Ikawa, Masatoshi Higuchi, Koichiro Ueki
  • Organizer: AAOMS 96th Annual meeting, scientific sessions & exhibition in conjunction with the Japanese society and Korean association of oral and maxillofacial surgeons
  • Place of Presentation: ホノルル（アメリカ合衆国）
  • Year and Date: 2014-09-08 – 2014-09-14
• [Presentation] 下顎頭軟骨修復におけるLIPUSの影響に関する実験的研究 (2014)
  • Author(s): 中澤隆一、諸井明徳、石原由梨、外堀恵、井川浩海、井口蘭、河阪明彦、樋口雅俊、丸川浩平、上木耕一郎
  • Organizer: 第68回NPO法人日本口腔科学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2014-05-08 – 2014-05-09
• [Presentation] Bone Regeneration by statin and low-intensity pulsed ultrasound (2013)
  • Author(s): Yuri Ishihara, Koichiro Ueki, Kohei Marukawa, Akinori Moroi, Megumi Sotobori, Ran Iguchi, Akihiko Kosaka, Yoshio Nakano, Masatoshi Higuchi, Ryuichi Nakazawa, Hiroumi, Ikawa
  • Organizer: 21st International Conference on Oral and Maxillofacial Surgery
  • Place of Presentation: Barcelona, Spain
• [Presentation] 異種材料メッシュにおける下顎骨欠損部位での骨再生の比較検討 (2013)
  • Author(s): 諸井明徳、井口蘭、河阪明彦、石原由梨、外堀恵、中澤龍一、樋口雅俊、中野佳央、丸川浩平、上木耕一郎
  • Organizer: 第58回日本口腔外科学会総会・学術大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡市）
• [Presentation] 下顎骨軟骨修復におけるLIPUSの影響に関する実験的研究 (2013)
  • Author(s): 中澤龍一、諸井明徳、石原由梨、外堀恵、井口蘭、河阪明彦、樋口雅俊、中野佳央、丸川浩平、上木耕一郎
  • Organizer: 第58回日本口腔外科学会総会・学術大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡市）