Research of the regulation of carcinoma by inhibition of nuclear receptor pathway.

Research Project

Project/Area Number	25861931
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Osaka University
Principal Investigator	TOMOTAKE Masuda 大阪大学, 歯学研究科(研究院), 招へい教員 (20510978)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	核内受容体 / 扁平上皮癌 / FABP4 / 増殖 / 浸潤 / 転移
Outline of Final Research Achievements	We have reported that PPARgamma is highly expressed in human oral squamous cell carcinoma, and regulate the pathway of FABP4. In this study, we found FABP4 is ectopically expressed on tumor cells in oral squamous cell carcinoma. Knockdown of FABP4 by siRNA in cultured cell lines of Squamous cell carcinoma dramatically suppressed the cellgrowth. These results imply a potentially important and novel role for the inhibition of FABP4 function in the treatment of squamous cell carcinoma and the preventeion of tumor invasion and metastasis.