Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Outline of Final Research Achievements |
We have reported that PPARgamma is highly expressed in human oral squamous cell carcinoma, and regulate the pathway of FABP4. In this study, we found FABP4 is ectopically expressed on tumor cells in oral squamous cell carcinoma. Knockdown of FABP4 by siRNA in cultured cell lines of Squamous cell carcinoma dramatically suppressed the cellgrowth. These results imply a potentially important and novel role for the inhibition of FABP4 function in the treatment of squamous cell carcinoma and the preventeion of tumor invasion and metastasis.
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