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Development of the tumor suppression therapy targeting GTP bound form of Ras by the irradiation of mild-Infrared laser

Research Project

Project/Area Number 25861938
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKobe University

Principal Investigator

Matsumoto Kousuke  神戸大学, 医学部附属病院, 特定助教 (30615951)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsレーザー / 分子振動 / DFGレーザー / リン酸結合
Outline of Final Research Achievements

Intravital molecular bonds have the matched infrared light frequencies respetively. It is significant that a mild-infrared laser which has the specific wavelength absorbed by the vibration of the target molecule achives the clivage for selective molecular bond. In this study, the phosphate bond of guanosine triphosphate (GTP) which relates the cell proliferation is the target molecule, and the purpose is identify the laser condition which achives the change of the substance of GTP. Nanosecond pulsed laser by difference-frequency generation laser was used in laser irradiation experiments and the absorption spectra of the pre and post irradiated sample of GTP were observed using a Fourier transform infrared spectrometer. It is possible that the specific conditon of mild-infrared laser identified in this study can achieve the conpositional change of the molecule.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Clinical investigation of carbon dioxide laser treatment for lingual leukoplakia2015

    • Author(s)
      Matsumoto K, Suzuki H, Asai T, Wakabayashi R, Enomoto Y, Kitayama M, Shigeoka M, Kimoto A, Takeuchi J, Yutori H, Komori T.
    • Journal Title

      Jounal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 27 Pages: 493-497

    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] 口腔扁平苔癬に対する炭酸ガスレーザー蒸散療法の臨床評価に関する前向き研究2015

    • Author(s)
      松本耕祐, 榎本由依, 小野真嵩, 小守紗也華, 北山美登里, 木本明, 鈴木泰明, 古森孝英
    • Journal Title

      日本レーザー歯学会誌

      Volume: 26 Pages: 124-129

    • NAID

      130005116302

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical investigation of vascular malformations of the oral region treated by multiple photocoagulation with an ND:YAG laser2015

    • Author(s)
      Matsumoto K,Ono M, Kitayama M, Akashi M, Suzuki H, Komori T.
    • Journal Title

      Oral Science in Japan 2015

      Volume: 2015 Pages: 63-65

    • NAID

      40021085562

    • Related Report
      2015 Annual Research Report
  • [Presentation] 中赤外領域レーザーによるリン酸結合切断をメカニズムとした新規分子標的治療の開発2015

    • Author(s)
      松本耕祐,石井克典,橋村圭亮,鈴木泰明,粟津邦男,古森孝英
    • Organizer
      第60回日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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