Development of the tumor suppression therapy targeting GTP bound form of Ras by the irradiation of mild-Infrared laser
Project/Area Number |
25861938
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
|
Research Institution | Kobe University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | レーザー / 分子振動 / DFGレーザー / リン酸結合 |
Outline of Final Research Achievements |
Intravital molecular bonds have the matched infrared light frequencies respetively. It is significant that a mild-infrared laser which has the specific wavelength absorbed by the vibration of the target molecule achives the clivage for selective molecular bond. In this study, the phosphate bond of guanosine triphosphate (GTP) which relates the cell proliferation is the target molecule, and the purpose is identify the laser condition which achives the change of the substance of GTP. Nanosecond pulsed laser by difference-frequency generation laser was used in laser irradiation experiments and the absorption spectra of the pre and post irradiated sample of GTP were observed using a Fourier transform infrared spectrometer. It is possible that the specific conditon of mild-infrared laser identified in this study can achieve the conpositional change of the molecule.
|
Report
(4 results)
Research Products
(4 results)
-
[Journal Article] Clinical investigation of carbon dioxide laser treatment for lingual leukoplakia2015
Author(s)
Matsumoto K, Suzuki H, Asai T, Wakabayashi R, Enomoto Y, Kitayama M, Shigeoka M, Kimoto A, Takeuchi J, Yutori H, Komori T.
-
Journal Title
Jounal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 27
Pages: 493-497
Related Report
Int'l Joint Research
-
-
-