Analysys of cytokine-induced EMT in oral squamous cell carcinoma cells.

Research Project

Project/Area Number	25861941
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Hiroshima University
Principal Investigator	OKUI gaku 広島大学, 大学病院, 歯科診療医 (00646888)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	上皮間葉移行 / 口腔扁平上皮癌 / 口腔癌
Outline of Final Research Achievements	Present study demonstrated that a Snail/Slug-dependent EMT program with parallel signaling that provides polarized cell motility via AKT is required to execute EMT . Our model will contribute to the basic understanding of how varied environmental conditions at a given stage in the cancer life cycle (e.g., stroma invasion vs. nest formation) may induce phenotypic changes (e.g., induction of EMT) in SCC cells, even if the EMT master regulator Snail is constitutively expressed at a high level.