The Bone Regenerative effect of Osteoblasts on Novel Hydroxyapatite Ceramics and Basic Study for Clinical application

Research Project

Project/Area Number	25861944
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Hiroshima University
Principal Investigator	TADA MISATO 広島大学, 大学病院, 歯科診療医 (40572326)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	多孔質セラミックス / ハイドロキシアパタイト / 骨芽細胞 / 骨再建材料 / ヒト骨芽細胞 / 骨分化マーカー
Outline of Final Research Achievements	IP-CHA (Interconnected Porous Calcium Hydroxyapatite) is an excellent ceramic for use in bone tissue engineering because of its fully interconnected porous structure, which allows osteoblasts dispersion and supports their osteogenic differentiation. This study provided biochemical evidence that the IP-CHA/osteoblasts composite and IP-CHA/osteoblasts/TGF-β1 (Transforming growth factor-β1) composite could enhance osteogenic potential. It was strongly suggested that IP-CHA was a useful biomaterial for bone tissue regeneration.