Molecular cytogenetic study of chromosomal amplification in oral cancer

Research Project

Project/Area Number	25861950
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Yamaguchi University
Principal Investigator	UCHIDA Kenichiro 山口大学, 医学部附属病院, 助教 (20379986)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	癌 / ゲノム / 細胞・組織
Outline of Final Research Achievements	The aim of this study is to investigate the biological role of chromosomal amplification in chromosome 8, and 11 and to clarify the genes canditating with amplification of these chromosomal region with over-expression in oral squamous cell carcinoma (OSCC). We comprehensively screened gene expression of 16 genes in 11q13 and 8 genes in 8q24.3. Three genes were identified as candidate gene in 11q13 and no gene associated in 8q24.3. The gene amplification correlated with the over-expression in 1 of 3 genes in 11q13. Amplification of this gene was observed in 13 of 50 OSCC cases. This result suggests that the gene relates with the development of OSCC.

Report

(3 results)