Development of a new therapy by Knockdown of the Brachyury for oral cancer stem cells

Research Project

Project/Area Number	25861958
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Kyushu University
Principal Investigator	KOBAYASHI YOSUKE 九州大学, 歯学研究科(研究院), 研究員 (60636554)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	Brachyury / chemotherapy / radiation / cancer stem cell / 癌幹細胞 / ノックダウン
Outline of Final Research Achievements	This study demonstrates that Brachyury knockdown reduces invasiveness and chemoresistance and radioresistance of Cancer stem cells in vivo. Therefore, Brachyury knockdown may be a useful therapeutic tool for sensitizing Cancer stem cells to conventional chemoradiotherapy.

Report

(3 results)