Development of a new therapy by Knockdown of the Brachyury for oral cancer stem cells
Project/Area Number |
25861958
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
|
Research Institution | Kyushu University |
Principal Investigator |
KOBAYASHI YOSUKE 九州大学, 歯学研究科(研究院), 研究員 (60636554)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | Brachyury / chemotherapy / radiation / cancer stem cell / 癌幹細胞 / ノックダウン |
Outline of Final Research Achievements |
This study demonstrates that Brachyury knockdown reduces invasiveness and chemoresistance and radioresistance of Cancer stem cells in vivo. Therefore, Brachyury knockdown may be a useful therapeutic tool for sensitizing Cancer stem cells to conventional chemoradiotherapy.
|
Report
(3 results)
Research Products
(1 results)