Selective hyperthermia using magnetic anti-cancer compound for neck metastasis of oral squamous cell carcinoma
| Project/Area Number |
25861964
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
IIDA Masaki 横浜市立大学, 附属病院, 指導診療医 (70613511)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔癌 / ハイパーサーミア / 新規磁性抗癌剤 / 頸部リンパ節転移 / 新規磁性体 / ヒト由来扁平上皮癌OSC19細胞 |
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| Outline of Final Research Achievements |
Patients of oral squamous cell carcinoma with bulky or multiple cervical lymph node metastases have a poor prognosis. Our strategy for these patients is the chemoradiotherapy using superselective intra-arterial infusion combined with hyperthermia. On the other hand, we developed new compound for magnet-guided delivery with anti-cancer activity named EI236. This compound has a magnetic property, so it can be used for thermochemotherapy. This study was to evaluate the anti-cancer efficacy of this new drug. We evaluated the combined two-fold strategy, i.e., chemotherapy with EI236 and alternating magnetic field induced heating of this drug to induce local hyperthermia, in both cultured cancer cells and cancer-bearing nude mouse. We found this new drug is effective as anti-cancer agent in both cultured cancer cells and mouse model of tongue cancer, and that alternating magnetic field exposure enhanced the anti-cancer effect.
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Report
(4 results)
Research Products
(8 results)
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[Presentation] Clinical evaluation of thermochemoradiotherapy using retrograde superselective intra-arterial infusion for advanced oral cancer with cervical lymph node metastases2014
Author(s)
Iida M, Mitsudo K, Ohara Y, Ohya T, Koizumi T, Nakashima H, Iwai T, Oguri S, Kioi M, Hirota M, Tohnai I
Organizer
American Association of Oral and Maxillofacial Surgeons 96th Annual Meeting
Place of Presentation
Honolulu(USA)
Year and Date
2014-09-08 – 2014-09-13
Related Report
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[Presentation] Clinical evaluation of thermochemoradiotherapy using retrograde superselective intra-arterial infusion for advanced oral squamous cell carcinoma with cervical lymph node metastases2014
Author(s)
Iida M, Mitsudo K, Ohara Y, Ohya T, Koizumi T, Nakashima H, Iwai T, Oguri S, Kioi M, Hirota M, Tohnai I
Organizer
6th Asian Congress of Hyperthermic Oncology
Place of Presentation
AOSSA（福井県福井市）
Year and Date
2014-09-05 – 2014-09-06
Related Report
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