| Project/Area Number |
25861964
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
IIDA Masaki 横浜市立大学, 附属病院, 指導診療医 (70613511)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔癌 / ハイパーサーミア / 新規磁性抗癌剤 / 頸部リンパ節転移 / 新規磁性体 / ヒト由来扁平上皮癌OSC19細胞 |
|---|
| Outline of Final Research Achievements |
Patients of oral squamous cell carcinoma with bulky or multiple cervical lymph node metastases have a poor prognosis. Our strategy for these patients is the chemoradiotherapy using superselective intra-arterial infusion combined with hyperthermia. On the other hand, we developed new compound for magnet-guided delivery with anti-cancer activity named EI236. This compound has a magnetic property, so it can be used for thermochemotherapy. This study was to evaluate the anti-cancer efficacy of this new drug. We evaluated the combined two-fold strategy, i.e., chemotherapy with EI236 and alternating magnetic field induced heating of this drug to induce local hyperthermia, in both cultured cancer cells and cancer-bearing nude mouse. We found this new drug is effective as anti-cancer agent in both cultured cancer cells and mouse model of tongue cancer, and that alternating magnetic field exposure enhanced the anti-cancer effect.
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