Search of transcription factor for BRAK by using new method in Head and neck carcinoma
| Project/Area Number |
25861982
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
IKOMA Takeharu 神奈川歯科大学, 歯学研究科(研究院), 助教 (10638290)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | BRAK / 転写因子 / CXCL14 / サイトカイン / 細胞分化 |
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| Outline of Final Research Achievements |
We previously reported that CpG island in the BRAK promoter region are associated with the expression of BRAK. In additon, we revealed that binding of transcription factor SP1 to a CpG island upstream of the BRAK transcription start site. In this reseach, we analyzed that the transcription factar of down-regulate the expression of BRAK.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.2014
Author(s)
Miyamoto C1, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.
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Journal Title
Biomedical Research
Volume: 35
Pages: 381-388
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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