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Search of transcription factor for BRAK by using new method in Head and neck carcinoma

Research Project

Project/Area Number 25861982
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

IKOMA Takeharu  神奈川歯科大学, 歯学研究科(研究院), 助教 (10638290)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsBRAK / 転写因子 / CXCL14 / サイトカイン / 細胞分化
Outline of Final Research Achievements

We previously reported that CpG island in the BRAK promoter region are associated with the expression of BRAK. In additon, we revealed that binding of transcription factor SP1 to a CpG island upstream of the BRAK transcription start site. In this reseach, we analyzed that the transcription factar of down-regulate the expression of BRAK.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.2014

    • Author(s)
      Miyamoto C1, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.
    • Journal Title

      Biomedical Research

      Volume: 35 Pages: 381-388

    • NAID

      130004903867

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] CXCL14のメチル化異常に着目したセツキシマブの抗腫瘍効果判定のための基礎研究2014

    • Author(s)
      近藤忠稚、小澤重幸、生駒丈晴、鈴木健司、久保田英朗
    • Organizer
      日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉 (幕張メッセ)
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] セツキシマブによる抗腫瘍性ケモカインBRAKの発現上昇メカニズムの解明2013

    • Author(s)
      小澤重幸、近藤忠稚、生駒丈晴、鈴木健司、久保田英朗
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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