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Leptin Promotes Wound Healing in the Skin and Oral Moucosa

Research Project

Project/Area Number 25861984
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionTsurumi University

Principal Investigator

IDE Shinji  鶴見大学, 歯学部, 助手 (00611998)

Research Collaborator SATOMURA Kazuhito  
TOKUYAMA Reiko  
TADOKORO Susumu  
UMEKI Hirochika  
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsレプチン / 創傷治癒 / 皮膚 / 口腔粘膜
Outline of Final Research Achievements

Leptin, a 16 kDa anti-obesity hormone, exhibits various physiological properties. Interestingly, skin wound healing was proven to delay in leptin-deficient ob/ob mice. However, little is known on the mechanisms of this phenomenon. In this study, we attempted to elucidate a role of leptin in wound healing of skin and oral mucosa.
Topically administered leptin was proven to promote wound healing in the skin by accelerating proliferation, differentiation/function and migration of epidermal keratinocytes and enhancing angiogenesis around the wounded area. These results strongly suggest that topical administration of leptin may be useful as a treatment to promote wound healing in the skin.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (9 results)

  • [Journal Article] Leptin promotes wound healing in the skin.2015

    • Author(s)
      Susumu Tadokoro, Shinji Ide, Reiko Tokuyama, Hirochika Umeki, Tatehara Seiko, Shiki Kataoka, Kazuhito Satomura
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 3 Pages: e0121242-e0121242

    • DOI

      10.1371/journal.pone.0121242

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Leptin promotes wound healing in the Oral mucosa.2014

    • Author(s)
      Hirochika Umeki, Reiko Tokuyama, Shinji Ide, Shimozuma Masashi, Susumu Tadokoro, Tatehara Seiko, Kazuhito Satomura
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 7 Pages: e101984-e101984

    • DOI

      10.1371/journal.pone.0101984

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 皮膚創傷治癒におけるメトレレプチンの役割2014

    • Author(s)
      井出 信次, 徳山 麗子, 梅木 泰親, 田所 晋, 大久保 充, 竹部 祐生亮, 舘原 誠晃, 里村 一人
    • Organizer
      第27回日本口腔診断学会・第24回日本口腔内科学会合同学術大会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県福岡市)
    • Year and Date
      2014-09-19 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] レプチンの口腔粘膜創傷治癒促進効果2014

    • Author(s)
      梅木 泰親, 徳山 麗子, 井出 信次, 大久保 充, 田所 晋, 舘原 誠晃, 里村 一人
    • Organizer
      第27回日本口腔診断学会・第24回日本口腔内科学会合同学術大会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県福岡市)
    • Year and Date
      2014-09-19 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Leptin promotes wound healing in the skin.2013

    • Author(s)
      Shinji Ide, Reiko Tokuyama, Hirochika Umeki, Susumu Tadokoro, Seiko Tatehara, Kazuhito Satomura
    • Organizer
      The 21st ICOMS
    • Place of Presentation
      Barcelona
    • Related Report
      2013 Research-status Report
  • [Presentation] Leptin promotes wound healing in the Oral mucosa.2013

    • Author(s)
      Hirochika Umeki, Reiko Tokuyama, Shinji Ide, Shimozuma Masashi, Susumu Tadokoro, Tatehara Seiko, Kazuhito Satomura
    • Organizer
      The 21st ICOMS
    • Place of Presentation
      Barcelona
    • Related Report
      2013 Research-status Report
  • [Presentation] レプチンの口腔粘膜創傷治癒促進効果2013

    • Author(s)
      梅木 泰親, 徳山 麗子, 井出 信次, 下間 雅史, 田所 晋, 舘原 誠晃, 片岡 志基, 鎌田 伸之, 里村 一人
    • Organizer
      第58日本口腔外科学会総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 皮膚創傷治癒におけるレプチンの役割2013

    • Author(s)
      井出 信次, 徳山 麗子, 梅木 泰親, 田所 晋, 舘原 誠晃, 里村 一人
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜会議センター
    • Related Report
      2013 Research-status Report
  • [Presentation] 口腔粘膜におけるレプチンの役割2013

    • Author(s)
      梅木 泰親, 井出 信次, 徳山 麗子, 田所 晋, 大久保 充, 竹部 裕生亮, 熊坂 祝, 舘原 誠晃, 鎌田 伸之, 里村 一人
    • Organizer
      第13回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜会議センター
    • Related Report
      2013 Research-status Report
  • [Presentation] レプチンによる皮膚創傷治癒のメカニズムの解明2013

    • Author(s)
      井出 信次, 徳山 麗子, 梅木 泰親, 田所 晋, 舘原 誠晃, 里村 一人
    • Organizer
      第67回日本口腔科学会総会
    • Place of Presentation
      栃木県総合文化センター
    • Related Report
      2013 Research-status Report
  • [Presentation] レプチンによる口腔粘膜創傷治癒の可能性2013

    • Author(s)
      梅木 泰親, 井出 信次, 徳山 麗子, 田所 晋, 大久保 充, 竹部 裕生亮, 熊坂 祝, 舘原 誠晃, 鎌田 伸之, 里村 一人
    • Organizer
      第67回日本口腔科学会総会
    • Place of Presentation
      栃木県総合文化センター
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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