Leptin Promotes Wound Healing in the Skin and Oral Moucosa
Project/Area Number |
25861984
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Tsurumi University |
Principal Investigator |
IDE Shinji 鶴見大学, 歯学部, 助手 (00611998)
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Research Collaborator |
SATOMURA Kazuhito
TOKUYAMA Reiko
TADOKORO Susumu
UMEKI Hirochika
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | レプチン / 創傷治癒 / 皮膚 / 口腔粘膜 |
Outline of Final Research Achievements |
Leptin, a 16 kDa anti-obesity hormone, exhibits various physiological properties. Interestingly, skin wound healing was proven to delay in leptin-deficient ob/ob mice. However, little is known on the mechanisms of this phenomenon. In this study, we attempted to elucidate a role of leptin in wound healing of skin and oral mucosa. Topically administered leptin was proven to promote wound healing in the skin by accelerating proliferation, differentiation/function and migration of epidermal keratinocytes and enhancing angiogenesis around the wounded area. These results strongly suggest that topical administration of leptin may be useful as a treatment to promote wound healing in the skin.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Leptin promotes wound healing in the skin.2015
Author(s)
Susumu Tadokoro, Shinji Ide, Reiko Tokuyama, Hirochika Umeki, Tatehara Seiko, Shiki Kataoka, Kazuhito Satomura
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Journal Title
PLOS ONE
Volume: 10
Issue: 3
Pages: e0121242-e0121242
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 皮膚創傷治癒におけるメトレレプチンの役割2014
Author(s)
井出 信次, 徳山 麗子, 梅木 泰親, 田所 晋, 大久保 充, 竹部 祐生亮, 舘原 誠晃, 里村 一人
Organizer
第27回日本口腔診断学会・第24回日本口腔内科学会合同学術大会
Place of Presentation
九州大学医学部百年講堂(福岡県福岡市)
Year and Date
2014-09-19 – 2014-09-20
Related Report
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[Presentation] レプチンの口腔粘膜創傷治癒促進効果2014
Author(s)
梅木 泰親, 徳山 麗子, 井出 信次, 大久保 充, 田所 晋, 舘原 誠晃, 里村 一人
Organizer
第27回日本口腔診断学会・第24回日本口腔内科学会合同学術大会
Place of Presentation
九州大学医学部百年講堂(福岡県福岡市)
Year and Date
2014-09-19 – 2014-09-20
Related Report
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[Presentation] 口腔粘膜におけるレプチンの役割2013
Author(s)
梅木 泰親, 井出 信次, 徳山 麗子, 田所 晋, 大久保 充, 竹部 裕生亮, 熊坂 祝, 舘原 誠晃, 鎌田 伸之, 里村 一人
Organizer
第13回日本抗加齢医学会総会
Place of Presentation
パシフィコ横浜会議センター
Related Report
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