The inositol prevents occurrence of cleft llip and palate
| Project/Area Number |
25861986
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Toyama (2014-2015)
Aichi Gakuin University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 口唇口蓋裂 / MLPA法 / Prop1 / 遺伝子 / PROP / 口蓋裂 / DNA / Wnt/βCatenin singnaling |
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| Outline of Final Research Achievements |
Cleft lip and palate are most frequent congenital anomaly, and the cause elucidation of this anomaly to hold many problems is expected, but there is not a yet definite thing. In the precedent study, the incidence of the cleft palate tended to be prevented by giving Inositol to a mouse.
Therefore, in this study, it was intended to clarify association with Inositol and Wnt signaling. I examined it mainly on connection with PROP1. As a result, I was not able to accept clear gene abnormality by the MLPA method. I did not recognize abnormality about other LHX4, some genes including HESX1 either.
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Report
(4 results)
Research Products
(3 results)
