| Project/Area Number |
25861992
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | モデル動物 / 不正咬合自然発症 / 鼻中隔軟骨 |
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| Outline of Final Research Achievements |
The purpose of this study was to elucidate the pathogenesis of malocclusion by focusing on inferior growth of the anterior cranial base and the nose in BALB/c-bm/bm mouse which spontaneously induces malocclusion.As begin this study, BALB/c-bm/bm mouse was infected the Pasteurella pneumotropica.Therefore, it was decided to try creating a new animal model.Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) play an important role in the differentiation and the formation of cartilage.So, it was succeeded to create a new animal model which have a variant PTH / PTHrP receptor, gene mutations have been inserted in the DNA sequence.
In the future, it is planned to evaluate the histological findings of bone and cartilage at the nasal septal cartilage in embryonic and masticatory performance using variant PTH / PTHrP receptor mouse and BALB/c-bm/bm mouse which spontaneously induces malocclusion.
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