| Project/Area Number |
25862016
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KUNIMATSU Ryo 広島大学, 医歯薬保健学研究院(歯), 助教 (40580915)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医学 / シグナル伝達 / レーザー / 代謝活性 / 歯周組織 / 矯正歯科 |
|---|
| Outline of Final Research Achievements |
It is demonstrated that a low-level laser irradiation enhances the proliferation of human periodontal lineage lineage cells and dental pulp cells by up-regulated ATP.
In addition, diode laser irradiation up-regulated the expressions of bone specific marker and mineralization activity in the osteogenic differentiation of human periodontal lineage cells and dental pulp cells. In vivo studies,it is demonstrated that irradiation of a low-level laser. It is thus confirmed that accelerated orthodontic tooth movement significantly. Laser irradiation may contribute to the regeneration of periodontal lineage tissues in terms of the enhancement of human cementoblast lineage cells proliferation and differentiation, suggesting that the application of a low-level laser could accelerate orthodontic movement.
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