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The dental trial and analysis of medicating natural flavonoid compounds to orthodontic tooth movement for preventing root resorption and promoting movement

Research Project

Project/Area Number 25862024
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

MORITA Yukiko  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (00631574)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯根吸収 / 矯正学的歯の移動 / フラボノイド / 歯の移動
Outline of Final Research Achievements

The aim of this study was to investigate the effect of flavonoids on orthodontic tooth movement and root resorption caused by it. It equipped with the closed coil spring of upper incisor part alveolar bone of a mouse, and between the first molar of left hand side, and carried out tooth movement. Typical three flavonoids known as related to bone metabolism and anti-inflammatry were selected and medicated to local area. 12days afterward, the distance between the second molar were measured by μCT. After extraction, root resorption was assessed by scanning electron microscopy on the pressure side of the mesial side of distobuccal root of the first molar. In each flavonoid medication group and the control group, the significant difference was not observed in the amount of tooth movements and root resorption. However, since optimal quantity of each flavonoid is unknown, it seems first that examination is required about optimal given dose and opitimal orthodontic force from now on.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] IL-12 Inhibits Lipopolysaccharide Stimulated Osteoclastogenesis in Mice2015

    • Author(s)
      Masako Yoshimatsu, Hideki Kitaura, Yuji Fujimura, Haruka Kohara, Yukiko Morita, and Noriaki Yoshida
    • Journal Title

      Journal of Immunology Research

      Volume: 2015 Pages: 1-8

    • DOI

      10.1155/2015/214878

    • NAID

      120006987060

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Investigation into cephalometric predictor variables determining surgery or non-surgery in skeletal Class Ⅲ cases.2016

    • Author(s)
      Yukiko Morita, Hitoshi Hotokezaka, Yoshiyuki Koga, Keira Arizono, Noriaki Yoshida
    • Organizer
      The 92nd Congress of the European Orthodontic Society
    • Place of Presentation
      ストックホルム(スウェーデン)
    • Year and Date
      2016-06-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Corticision increased alveolar bone resorption in proportion to the amount of cut volume, but did not affect any effect on orthodontic tooth movement.2016

    • Author(s)
      Hitoshi Hotokezaka, Yukiko Morita, Takeshi Kurohama, Megumi Hashimoto, Noriaki Yoshida
    • Organizer
      The 92nd Congress of the European Orthodontic Society
    • Place of Presentation
      ストックホルム(スウェーデン)
    • Year and Date
      2016-06-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recent trends in treatment approaches to ClassⅢ malocclusion cases at Nagasaki University Hospital.2015

    • Author(s)
      Yukiko Morita
    • Organizer
      第十回台湾口腔矯正医学会(TOS)
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ベトナム人口唇裂および口蓋裂未手術患者の顎発育に関する調査 -第2報 成人2症例2015

    • Author(s)
      森田幸子,井村英人,新美照幸,大野磨弥,佐久間千里,夏目長門
    • Organizer
      第55回日本先天異常学会学術集会
    • Place of Presentation
      パシフィコ横浜会議センター(横浜)
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] ベトナム人未手術患者の顎発育に関する調査-第1報 日本人患者との比較-2015

    • Author(s)
      森田幸子,藤村裕治,井村英人,新美照幸,大野磨弥,佐久間千里,夏目長門,吉田教明
    • Organizer
      第39回日本口蓋裂学会総会・学術集会
    • Place of Presentation
      シェーンバッハ・サボー(砂防会館)(東京)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 愛知学院大学口唇口蓋裂センターにおける上顎前方牽引の効果-第2報 乳歯列より開始した症例の骨格変化-2015

    • Author(s)
      森田幸子,井村英人,増田浩男,新美照幸,古川博雄,大野磨弥,森明弘,佐久間千里,夏目長門
    • Organizer
      第39回日本口蓋裂学会総会・学術集会
    • Place of Presentation
      シェーンバッハ・サボー(砂防会館)((東京)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 愛知学院大学口唇口蓋裂センターにおける上顎前方牽引の効果-第1報 実施群と非実施群の比較-2015

    • Author(s)
      井村英人,森田幸子,増田浩男,新美照幸,古川博雄,大野磨弥,森明弘,佐久間千里,夏目長門
    • Organizer
      第39回日本口蓋裂学会総会・学術集会
    • Place of Presentation
      シェーンバッハ・サボー(砂防会館)((東京)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] A case of extremely low birth weight infant with cleft.2014

    • Author(s)
      Y. Fujimura, Y. Morita, H. Hotokezaka, J. Tominaga, D. Utsumi, S. Iijima, N. Yoshida
    • Organizer
      ICPF 2014 Workshop In Conjunction with 5th Congress of MAOMS
    • Place of Presentation
      Ulaanbaatar, MONGOLIA
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] LPSによる破骨細胞形成に対するIL-12の抑制機序2013

    • Author(s)
      吉松 昌子, 北浦 英樹, 藤村 裕治, 小原 悠, 森田 幸子, 吉田 教明
    • Organizer
      日本矯正歯科学会
    • Place of Presentation
      キッセイ文化ホール(松本市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 矯正学的歯の移動時における歯根吸収に対するIFN-γの作用について2013

    • Author(s)
      小原 悠, 北浦 英樹, 吉松 昌子, 藤村 裕治, 吉田 教明
    • Organizer
      日本矯正歯科学会
    • Place of Presentation
      キッセイ文化ホール(松本市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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