| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Of the different kinds of pain that are empirically known during orthodontic treatment, there is the kind of pain which is felt only when chewing (occlusal pain), which is not the kind of pain that is felt without doing anything. In this study, we investigated the pathogenesis of occlusal pain. As we knew that pain was transmitted by ATP which was well known as the currency of cellular energy, we carried out our investigation by focusing on ATP.
The results of our study suggested the possibility that within the trigeminal ganglion that had received the pain after the tooth extraction of the rats, ATP transmitted information to the separated site and increased the pain. They suggested the possibility that ATP was involved in the transmission of tooth pain as well.
By revealing the pathogenesis of "pain" that the patient feels during orthodontic treatment, these results can be expected to contribute to our efforts to overcome pain.
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