Investigation of Hyperalgesia caused by orthodontic treatment
Project/Area Number |
25862027
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Orthodontics/Pediatric dentistry
|
Research Institution | Kyushu Dental College |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 歯科矯正学 / 三叉神経節 / ATP / VNUT / 象牙芽細胞 / サテライト細胞 |
Outline of Final Research Achievements |
Of the different kinds of pain that are empirically known during orthodontic treatment, there is the kind of pain which is felt only when chewing (occlusal pain), which is not the kind of pain that is felt without doing anything. In this study, we investigated the pathogenesis of occlusal pain. As we knew that pain was transmitted by ATP which was well known as the currency of cellular energy, we carried out our investigation by focusing on ATP. The results of our study suggested the possibility that within the trigeminal ganglion that had received the pain after the tooth extraction of the rats, ATP transmitted information to the separated site and increased the pain. They suggested the possibility that ATP was involved in the transmission of tooth pain as well. By revealing the pathogenesis of "pain" that the patient feels during orthodontic treatment, these results can be expected to contribute to our efforts to overcome pain.
|
Report
(4 results)
Research Products
(8 results)
-
[Journal Article] Expression of vesicular nucleotide transporter in rat odontoblasts.2016
Author(s)
Ikeda E., Goto T., Gunjigake K., Kuroishi K., Ueda M., Kataoka S., Toyono T., Nakatomi M., Seta Y., Kitamura C., Nishihara T and Kawamoto T
-
Journal Title
Acta Histochemica et Cytochemica
Volume: 49
Pages: 21-28
NAID
Related Report
Peer Reviewed / Open Access
-
-
[Presentation] The expression of VNUT in rat odontoblasts.2016
Author(s)
Ikeda E., Goto T., Gunjigake K.K., Kuroishi K.N., Ueda M., Kataoka S., Toyono T., Nakatomi M., Seta Y., Kitamura C., Nishihara T. and Kawamoto T
Organizer
Interdisciplinary Medical, Dental and Soft-material Researches on the move-Showcase Review at Kitakyushu-
Place of Presentation
Kitakyushu
Year and Date
2016-01-22
Related Report
Int'l Joint Research
-
-
-
-
-