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Effects of sumoylation on periodontal regeneration therapy

Research Project

Project/Area Number 25862045
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Periodontology
Research InstitutionOsaka University

Principal Investigator

KITAGAKI Jirouta  大阪大学, 歯学部附属病院, 助教 (90570292)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsスモ化システム / ユビキチン化システム / 歯周組織再生 / ボルテゾミブ / 歯根膜細胞 / Wntシグナル
Outline of Final Research Achievements

The purpose of this study is to identify the effects of sumoylation, which is one of the protein modification systems, on periodontal regeneration therapy. We identified the crosstalk between sumoylation and other protein modification systems ubiquitination. Therefore, we analyzed the role of ubiquitination on cytodifferentiation and mineralization of periodontal ligament cells. Bortezomib, one of the proteasome inhibitors, clearly induced the cytodifferentiation and mineralization of periodontal ligament cells through induction of Wnt signaling. Moreover, bortezomib enhanced the BMP-2-induced cytodifferentiation and mineralization of periodontal ligament cells. These data indicates that bortezomib might be an useful compound for periodontal regeneration therapy.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Cyclic depsipeptides as potential cancer therapeutics2015

    • Author(s)
      Jirouta Kitagaki, Genbin Shi, Shizuka Miyauchi, Shinya Murakami, Yili Yang
    • Journal Title

      Anti-Cancer Drugs

      Volume: 26 Issue: 3 Pages: 259-71

    • DOI

      10.1097/cad.0000000000000183

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of proteasome inhibitor bortezomib on cytodifferentiation and mineralization of periodontal ligament cells2014

    • Author(s)
      J Kitagaki, S Miyauchi1, C Xie, M Yamashita, S Yamada, M Kitamura, S Murakami.
    • Journal Title

      J Periodont Res

      Volume: 50 Issue: 2 Pages: 248-255

    • DOI

      10.1111/jre.12202

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Effects of proteasome inhibitor bortezomib on periodontal ligament cell differentiation2014

    • Author(s)
      Shizuka Miyauchi, Jirouta Kitagaki, Motozo Yamashita, Satoru Yamada, Masahiro Kitamura, Shinya Murakami
    • Organizer
      第62回国際歯科研究学会日本部会(JADR)学術大会
    • Place of Presentation
      KKRホテル
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of proteasome inhibitor bortezomib on cytodifferentiation and mineralization of periodontal ligament cells2014

    • Author(s)
      Jirouta Kitagaki, Shizuka Miyauchi, Motozo Yamashita, Satoru Yamada, Masahiro Kitamura, Shinya Murakami
    • Organizer
      2014 Kyungpook-Osaka University International Symposium
    • Place of Presentation
      Kyungpook National University School of Dentistry
    • Year and Date
      2014-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロテアソーム阻害剤ボルテゾミブの歯根膜細胞の石灰化制御2013

    • Author(s)
      北垣次郎太、謝成ショウ、中村友美、粟田敏仁、森健太、久保田実木子、阪下裕美、山本智美、池上久仁子、小笹匡雄、竹立匡秀、柳田学、山下元三、山田聡、北村正博、村上伸也
    • Organizer
      第138回 日本歯科保存学会2013年度春季学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] Roles of proteasome inhibitor bortezomib in periodontal ligament cell differentiation2013

    • Author(s)
      C Xie, J Kitagaki, S Miyauchi, M Yamashita, S Yamada, M Kitamura, and S Murakami
    • Organizer
      2nd Meeting of the International Association for Dental Research - Asia Pacific Region
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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