| Project/Area Number |
25862045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | スモ化システム / ユビキチン化システム / 歯周組織再生 / ボルテゾミブ / 歯根膜細胞 / Wntシグナル |
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| Outline of Final Research Achievements |
The purpose of this study is to identify the effects of sumoylation, which is one of the protein modification systems, on periodontal regeneration therapy. We identified the crosstalk between sumoylation and other protein modification systems ubiquitination. Therefore, we analyzed the role of ubiquitination on cytodifferentiation and mineralization of periodontal ligament cells. Bortezomib, one of the proteasome inhibitors, clearly induced the cytodifferentiation and mineralization of periodontal ligament cells through induction of Wnt signaling. Moreover, bortezomib enhanced the BMP-2-induced cytodifferentiation and mineralization of periodontal ligament cells. These data indicates that bortezomib might be an useful compound for periodontal regeneration therapy.
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