Regulation of mechanical stress-induced responses by adenosine in periodontal tissue

Research Project

Project/Area Number	25862046
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Periodontology
Research Institution	Osaka University
Principal Investigator	TAKEDACHI Masahide 大阪大学, 歯学研究科(研究院), 助教 (60452447)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	アデノシン / 歯根膜 / メカニカルストレス
Outline of Final Research Achievements	In this study, the roles of adenosine in mechanical stress-induced responses in periodontal tissue were analyzed. In vitro tensile mechanical stress didn’t impact the adenosine receptor (AdoR) expressions of human periodontal ligament cells. On the other hand, the expression of CD73 was up-regulated at tension sites in the periodontal ligament under orthodontic tooth movement in a mouse model. In addition, orthodontic tooth movement made periodontal ligament a hypoxic condition. Moreover, hypoxic condition might affect the AdoR expression of human periodontal ligament cells in vitro.

Report

(3 results)